Lipase-catalyzed transesterification of trans-2,5-disubstituted pyrrolidines: Effect of substituent on enantioselectivity

Authors
Kawanami, Y Iizuna, N Okano, K
Citation
Y. Kawanami et al., Lipase-catalyzed transesterification of trans-2,5-disubstituted pyrrolidines: Effect of substituent on enantioselectivity, CHEM LETT, (12), 1998, pp. 1231-1232
Citations number
22
Categorie Soggetti
Chemistry
Journal title
CHEMISTRY LETTERS
ISSN journal
03667022 → ACNP
Issue
12
Year of publication
1998
Pages
1231 - 1232
Database
ISI
SICI code
0366-7022(199812):12<1231:LTOTP>2.0.ZU;2-G
Abstract
Kinetic resolution of racemic N-arylmethylated trans-2-acetoxy-methyl-5-hyd roxymethylpyrrolidines by using lipase-catalyzed transesterification has be en studied. The enantioselectivity depends significantly on the structure o f the aryl ring and N-3,5-dimethylbenzylpyrrolidine was found to be the bes t substrate for the present reaction.