In the case of a criticality accident, there are two radiation compone
nts, i.e. neutron and gamma, and the exposure is heterogeneous. The av
ailable techniques are biophysical techniques, which can give data abo
ut the dose distribution and the neutron component dose, classical tec
hniques (electroencephalography, lymphocytes counting, dicentric and a
centric fragments counting, biochemical indicators) which can give an
estimation of the mean biological dose, new biochemical parameters whi
ch are good indicators of vital prognosis and new cytogenetic techniqu
es under study. Biological dosimetry or rather research of biological
indicators of irradiation remains difficult, particularly because of t
he heterogeneity of exposure. A multiparametric determination seems th
e only solution.