Chronic subdural haematoma: a possible relationship with tamoxifen

Five patients operated on between 6 months and 7 years earlier for breast c ancer were surgically treated for chronic subdural haematoma. This unusual association may be explained on the basis of known factors such as coagulat ive impairment subsequent to chemotherapy, a degree of cerebral atrophy or mild trauma. On the other hand, since four of the patients were taking anti oestrogen therapy to control the disease, it is speculated that the oestrog enic properties of tamoxifen may have contributed to subdural bleeding. (C) 1998 Published by Elsevier Science B.V. AU rights reserved.