A forward model for maximum expiration

The maximum expiratory flow-volume (MEFV) curve is a sensitive test of resp iratory mechanics. Several mathematical models for forced expiration have b een developed, but they suffer from various shortcomings. It is impossible to calculate the parts of the MEFV curve beyond the flow limiting condition s and computational algorithms do not allow a direct calculation of maximal flow. In the present work a complex, nonlinear forward model, including ex citing signal and static recoil pressure-lung volume descriptions and 132 p arameters, has been constructed. Direct determination of maximum flow is ac hieved by means of successive approximation algorithm. The model enables pr ediction of flow during forced expiration in the whole range of forced vita l capacity. (C) 1998 Elsevier Science Ltd. All rights reserved.