Regulation of mineralocorticoid biosynthesis by calcium and the StAR protein

Citation
N. Cherradi et al., Regulation of mineralocorticoid biosynthesis by calcium and the StAR protein, ENDOCRINE R, 24(3-4), 1998, pp. 355-362
Citations number
13
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
ENDOCRINE RESEARCH
ISSN journal
07435800 → ACNP
Volume
24
Issue
3-4
Year of publication
1998
Pages
355 - 362
Database
ISI
SICI code
0743-5800(1998)24:3-4<355:ROMBBC>2.0.ZU;2-5
Abstract
In adrenal zona glomerulosa cells, the calcium messenger system is the majo r signaling mechanism activated by physiological stimulators of aldosterone production. We present here evidence for a dual site of action of the calc ium signal: 1) Calcium influx into the mitochondrion is a prerequisite to t he activation of steroidogenesis. This calcium entry leads to a rise in mit ochondrial calcium concentration and to an increase in intramitochondrial c holesterol transfer and Steroidogenic Acute Regulatory (StAR) protein accum ulation in inner mitochondrial membranes. 2) Calcium also exerts a genomic regulatory effect by activating transcription of the StAR gene.