Steroidogenic effect of peptide histidine-isoleucine (PHI) in vitro: Comparison with VIP

Authors
Nowak, KW Malendowicz, LK
Citation
Kw. Nowak et Lk. Malendowicz, Steroidogenic effect of peptide histidine-isoleucine (PHI) in vitro: Comparison with VIP, ENDOCRINE R, 24(3-4), 1998, pp. 759-762
Citations number
10
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
ENDOCRINE RESEARCH
ISSN journal
07435800 → ACNP
Volume
24
Issue
3-4
Year of publication
1998
Pages
759 - 762
Database
ISI
SICI code
0743-5800(1998)24:3-4<759:SEOPH(>2.0.ZU;2-F
Abstract
VIP and PHI originate from the same precursor, and the two peptides share c onsiderable sequence homology. Present studies, however, revealed notable d ifferences in their steroidogenic effect on isolated rat adrenocortical cel ls. VIP seems to act through the VIP and/or PACAP receptor while PHI acts, directly or by sensitivity increase, through the ACTH receptor.