Serum cholesterol and the risk of ductal carcinoma in situ: a case-controlstudy

While multiple studies have investigated the association between serum chol esterol level and breast cancer, the results have generally been conflictin g. No prior study has investigated its association with ductal carcinoma in situ (DCIS) of the breast. In this hospital-based case-control study, 152 DCIS cases were compared to 242 controls (patients with benign surgical con ditions), Unconditional logistic regression was used to compare the serum c holesterol levels, adjusting for relevant covariates, No statistically sign ificant difference was observed for different quartiles of the serum choles terol level as compared to the lowest quartile, Incidentally observed was a n elevated risk for DCIS in postmenopausal versus premenopausal women, and in peri-menopausal versus premenopausal women. There is no apparent associa tion between the serum cholesterol level and breast DCIS, (C) 1998 Lippinco tt Williams & Wilkins.