Human chorionic gonadotrophin luteal support overcomes luteal phase inadequacy after gonadotrophin-releasing hormone agonist-induced ovulation in gonadotrophin-stimulated cycles
J. Penarrubia et al., Human chorionic gonadotrophin luteal support overcomes luteal phase inadequacy after gonadotrophin-releasing hormone agonist-induced ovulation in gonadotrophin-stimulated cycles, HUM REPR, 13(12), 1998, pp. 3315-3318
Gonadotrophin-releasing hormone agonist (GnRHa)-induced ovulation after gon
adotrophin ovarian stimulation is used to prevent ovarian hyperstimulation
syndrome and multiple pregnancy in polyfollicular cycles. However, one of t
he major problems to be resolved is corpus luteum function after follicular
maturation and ovulation by midcycle GnRHa administration. The present rep
ort investigated the luteal phase in non-conceptual polyfollicular cycles i
n 26 patients (group 1) receiving a single dose of 0.5 mg leuprolide acetat
e to induce ovulation and in a control group of patients (n = 26) (group 2)
who were given human chorionic gonadotrophin (HCG) (10 000 IU i.m.) for ov
ulation induction. All of them were normal ovulatory women undergoing gonad
otrophin ovarian stimulation because of unexplained infertility or male fac
tor. In both groups of patients two doses of 2500 IU HCG i.m, were given 6
and 10 days after the ovulatory dose of HCG or GnRHa to support the luteal
phase. All cycles were ovulatory as shown by mid-luteal serum progesterone
concentrations >10 ng/ml, Mean serum progesterone concentrations were 62% h
igher in group 2 than in group 1, but this difference was not statistically
significant. The mean length of the luteal phase was similar in groups 1 a
nd 2. It is concluded that HCG luteal support is a useful tool to overcome
the luteal phase inadequacy that characterizes GnRHa-triggered cycles after
gonadotrophin stimulation.