Five homologous repeats of the protein G-related protein MIG cooperate in binding to goat immunoglobulin G

Authors
Vasi, J Svensson, J Frick, IM Muller, HP
Citation
J. Vasi et al., Five homologous repeats of the protein G-related protein MIG cooperate in binding to goat immunoglobulin G, INFEC IMMUN, 67(1), 1999, pp. 413-416
Citations number
17
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
67
Issue
1
Year of publication
1999
Pages
413 - 416
Database
ISI
SICI code
0019-9567(199901)67:1<413:FHROTP>2.0.ZU;2-F
Abstract
Protein MIG, from Streptococcus dysgalactiae, binds alpha(2)-macroglobulin and immunoglobulin G (IgG). MIG-derived fusion proteins with one to five Ig G-binding repeats differed up to 72,000-fold in avidity for goat IgG, indic ating a considerable cooperativity of the repeats. Significant sequence var iation in the IgG-binding repeats was recognized. Protein MIG interacted wi th goat IgG1 via both the Pc and Fab parts.