Soluble tumor necrosis factor alpha receptors in sera from leprosy patients

Authors
Munk, ME Anding, P Schettini, APM Cunha, MDGS Kaufmann, SHE
Citation
Me. Munk et al., Soluble tumor necrosis factor alpha receptors in sera from leprosy patients, INFEC IMMUN, 67(1), 1999, pp. 423-425
Citations number
19
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
67
Issue
1
Year of publication
1999
Pages
423 - 425
Database
ISI
SICI code
0019-9567(199901)67:1<423:STNFAR>2.0.ZU;2-7
Abstract
Serum levels of soluble tumor necrosis factor alpha receptor I (sTNF-RI) we re elevated in patients with lepromatous (LL) reactional-state type II lepr osy, and sTNF-RII levels were increased in patients with full tuberculoid ( TT) or LL type II leprosy. The sTNF-R in sera from patients with type II le prosy, but not other forms of leprosy, inhibited recombinant TNF cytolytic activities in vitro. This suggests that sTNF-R regulatory activities are pa rtially impaired in patients with leprosy.