gamma delta T-cell function in pathogenesis of cerebral malaria in mice infected with Plasmodium berghei ANKA

Authors
Yanez, DM Batchelder, J van der Heyde, HC Manning, DD Weidanz, WP
Citation
Dm. Yanez et al., gamma delta T-cell function in pathogenesis of cerebral malaria in mice infected with Plasmodium berghei ANKA, INFEC IMMUN, 67(1), 1999, pp. 446-448
Citations number
17
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
67
Issue
1
Year of publication
1999
Pages
446 - 448
Database
ISI
SICI code
0019-9567(199901)67:1<446:GDTFIP>2.0.ZU;2-D
Abstract
Mice depleted of gamma delta T cells by monoclonal antibody treatment and i nfected with Plasmodium berghei ANKA did not develop cerebral malaria (CRI) . In striking contrast, delta(0/0) mice infected with P. berghei developed CR;I despite their gamma delta T-cell deficiency, gamma delta T cells appea r to be essential for the pathogenesis of CM in mice having experienced nor mal ontogeny but not in mice genetically deprived of gamma delta T cells fr om the beginning of life.