A. Joachim et al., Changes in antigen and glycoprotein patterns during the development of Oesaphagostomum dentatum, INT J PARAS, 28(12), 1998, pp. 1853-1860
During its development from free-living infectious third-stage larvae to th
e adult worms in the large intestines of pigs, Oesophagostomum dentatum exp
eriences several environmental changes. Differences in protein patterns can
reflect such changes. Somatic and ES antigens and glycoproteins of pre-par
asitic, histotropic and intestinal stages were compared by single-dimension
SDS-PAGE and stage-specific proteins were defined. Furthermore, fourth-sta
ge larvae derived from different sources - in-vitro cultivation and intesti
nal contents - were compared and also found to be different. It is hypothes
ised that O. dentatum reacts to environmental stimuli by differential expre
ssion of specific proteins as a possible mode of adaptation to the host. (C
) 1998 Australian Society for Parasitology. Published by Elsevier Science L
td. All rights reserved.