V. Suvatte et al., Bone marrow, peripheral blood and cord blood stem cell transplantation in children: Ten years' experience at Siriraj Hospital, INT J HEMAT, 68(4), 1998, pp. 411-419
Stem cell transplantations were performed in 69 children at Siriraj Hospita
l over a ten year period. The source of stem cells was bone marrow (60), pe
ripheral blood (3), or cord blood (6). The diseases treated included 35 tha
lassemias, 11 Burkitt's lymphoma, five non-Hodgkin's lymphoma, five aplasti
c anemia, eight acute leukemia, and one each of neuroblastoma, severe combi
ned immunodeficiency, Wiskott-Aldrich syndrome, myelodysplastic syndrome, a
nd pyruvate kinase deficiency. The success rate of stem cell transplantatio
n in Thai children varied according to the underlying diseases of the patie
nts, ranging from 50%, in acute leukemia to 100% in aplastic anemia. The ou
tcome of stem cell transplantation in 35 thalassemic children revealed 23 (
79.4%) were cured, whereas three (10.3%) remain alive with disease and the
other three (10.3%) died. The incidence of graft-versus-host disease was lo
w hen compared with that of Western countries. It is concluded that bone ma
rrow, peripheral blood and cord blood stem cell transplantation will be the
treatment of choice and will be widely used in the future to cure many hem
atologic and malignant disorders in children. (C) 1998 Elsevier Science Ire
land Ltd. All rights reserved.