Previous studies of younger, healthy individuals have demonstrated an inver
se relationship between physical activity and depression. The present study
addressed the relation between self-reported physical activity and symptom
s of depression in 146 men and women aged 50 years and older with major dep
ressive disorder (MDD). Patients who met clinical criteria for MDD complete
d the Beck Depression Inventory (BDI) and the Minnesota Leisure-Time Activi
ty Questionnaire (MQ). Multiple regression analysis indicated that lower le
vels of physical activity were associated with more severe depressive sympt
oms (p = .04), after adjusting for age and gender. The implications of thes
e findings for the treatment and prevention of depression are discussed.