C. Heuer et al., Design of the simulated moving bed process based on adsorption isotherm measurements using a perturbation method, J CHROMAT A, 827(2), 1998, pp. 175-191
The design of a simulated moving bed (SMB) chromatography process for the e
nantioseparation of 1-phenoxy-2-propanol with Chiralcel OD as stationary ph
ase is described using equilibrium theory and a dispersion model. The most
essential prerequisite for reliable process simulation is the proper experi
mental determination of the corresponding adsorption isotherms. This paper
evolved from the need to: (i) elaborate a technique for adsorption isotherm
measurement based on a perturbation method; and (ii) to demonstrate the ap
plicability of the equilibrium-dispersion model for quick process design. T
he accuracy of the obtained adsorption isotherms was evaluated by compariso
n with results that have been obtained independently using the classical ad
sorption-desorption procedure. As the main result, it turned out that the s
uggested SMB design concept based both on adsorption isotherms measured wit
h the perturbation method and on the equilibrium-dispersion model could be
verified experimentally. (C) 1998 Elsevier Science B.V. All rights reserved
.