Atrium and paroxetine-related severe hepatitis

Two cases of severe hepatitis in young women using Atrium and paroxetine ar e presented. Both patients presented jaundice, marked increase in aminotran sferases activities, and pronounced prolongation in prothrombin time. In bo th cases, liver biopsy specimen examination revealed lesions compatible wit h drug-related injury. Other causes of hepatic injury were reasonably ruled out by complete careful screening. Outcome was marked by rapid complete re covery in one case and by slow recovery in the other. We suggest that simul taneous treatment with Atrium and paroxetine could increase each of these d rugs' hepatotoxicity.