Orthogonal polynomials associated with Delta(omega)-semi-classical function
als will be studied as a generalization of the Delta(omega)-classical funct
ionals. The concept of class and a criterion for determining it will be giv
en. The Delta(omega)-difference equation that the corresponding formal Stie
ltjes series satisfies is obtained. The quasi-orthogonality property satisf
ied by the Delta(omega)-differences of these polynomials is analyzed. Two s
tructure relations as well as a quadratic relation are obtained. The second
order difference equation is determined.