Human immunodeficiency virus type 1 subtypes differ in disease progression

At least 10 different genetic human immunodeficiency virus type 1 (HIV-1) s ubtypes (A-J) are responsible for the AIDS pandemic. Much of the understand ing of HIV-1 disease progression derives from studies in the developed worl d where HIV infection is almost exclusively subtype B. This has led many to question whether the properties and consequences of HIV-1 infection can be generalized across subtypes that afflict the majority of infected persons in the developing world. From 1985 to 1997, a prospective study of register ed female sex workers in Senegal tracked the introduction and spread of HIV -1 subtypes A, C, D, and G, In clinical follow-up, the AIDS-free survival c urves differed by HIV-1 subtype. Women infected with a non-A subtype were 8 times more likely to develop AIDS than were those infected with subtype A (hazard ratio = 8.23; P = .009), the predominant subtype in the study. Thes e data suggest that HIV-1 subtypes may differ in rates of progression to AI DS.