A novel EWS-ERG rearrangement generating two hybrid mRNAs in a peripheral primitive neuroectodermal tumour (PPNET) with a t(15;22) translocation

Authors
Minoletti, F Sozzi, G Tornielli, S Pilotti, S Azzarelli, A Pierotti, MA Radice, P
Citation
F. Minoletti et al., A novel EWS-ERG rearrangement generating two hybrid mRNAs in a peripheral primitive neuroectodermal tumour (PPNET) with a t(15;22) translocation, J PATHOLOGY, 186(4), 1998, pp. 434-437
Citations number
27
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research Diagnosis & Treatment
Journal title
JOURNAL OF PATHOLOGY
ISSN journal
00223417 → ACNP
Volume
186
Issue
4
Year of publication
1998
Pages
434 - 437
Database
ISI
SICI code
0022-3417(199812)186:4<434:ANERGT>2.0.ZU;2-B
Abstract
The occurrence of a t(15;22) translocation in a peripheral primitive neuroe ctodermal tumour (pPNET) has been previously reported, Molecular examinatio n revealed the presence in tumour mRNA of tno hybrid transcripts containing the 5' portion of the EWS gene fused to the 3' portion of the ERG gene. Se quence analyses indicated that both aberrant mRNAs most likely originated f rom the same rearrangement, which produced different hybrid isoforms doe to the presence of an alternatively spliced cion in the ERG gene, To the auth ors' knowledge, this is the first report of the detection of two hybrid EWS -ERG mRNAs within the same tumour. (C) 1998 John Wiley & Sons, Ltd.