Photoreactions of psoralens with lecithins

The formation of cyclobutane (cb) photoadducts of psoralen with a model lec ithin has been shown. The adducts are formed bath in ethanol solution and i n micellar suspension in water. In spite of their sensitivity to various fa ctors such as light, temperature, air, etc., they are isolated by thin-laye r chromatography (TLC) and high-pressure liquid chromatography (HPLC) and c haracterized by mass spectrometry, NMR and UV absorption spectroscopy. The NMR analysis indicates the similarity of isomeric forms of cb adducts in le cithin to those formed with free oleic acid. (C) 1998 Elsevier Science S.A. All rights reserved.