Salt effects on protein titration and binding

Salt effects on protein titration and binding are investigated using a cavi ty-function theory for chemical association. Analytical expressions are obt ained for the electrostatic interaction factor in protein titration and for the pK shift of the calcium-binding constant in calbindin D-9k Although th e structural details of proteins are neglected in the model, the theoretica l results are in excellent agreement with experimental data.