Synthesis and biological activities of aryl propargyl sulfone

Authors
Wu, MJ Lin, CF Chang, LJ Jing, PT Duh, TH Tseng, WT Lee, FC Wang, SS Chang, HO
Citation
Mj. Wu et al., Synthesis and biological activities of aryl propargyl sulfone, J CHIN CHEM, 45(6), 1998, pp. 783-788
Citations number
29
Categorie Soggetti
Chemistry
Journal title
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
ISSN journal
00094536 → ACNP
Volume
45
Issue
6
Year of publication
1998
Pages
783 - 788
Database
ISI
SICI code
0009-4536(199812)45:6<783:SABAOA>2.0.ZU;2-O
Abstract
A series of molecules containing monopropargyl sulfone or 1,2-bis-propargyl sulfone were synthesized. The cytotoxicity of these compounds against huma n carcinoma cells was also examined. This study indicated that the formatio n of a biradical intermediate is important to the potency of cytotoxicity.