A study on p53 protein and anti-p53 antibodies in the sera of patients with oesophageal cancer

Authors
Parashar, K Sobti, RC
Citation
K. Parashar et Rc. Sobti, A study on p53 protein and anti-p53 antibodies in the sera of patients with oesophageal cancer, MUT RES-F M, 422(2), 1998, pp. 271-277
Citations number
46
Categorie Soggetti
Molecular Biology & Genetics
Journal title
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
ISSN journal
13861964 → ACNP
Volume
422
Issue
2
Year of publication
1998
Pages
271 - 277
Database
ISI
SICI code
1386-1964(199812)422:2<271:ASOPPA>2.0.ZU;2-K
Abstract
p53 protein levels were examined in sera of 15 oesophageal cancer patients using the p53 monoclonal antibody PAb 1801. Antibodies specific for p53 wer e also analyzed in 20 patients (including 15 patients used for p53 protein level study) and 20 healthy controls. Anti-p53 antibodies were present in 3 0% (6/20) patients while no antibodies were detected in sera of healthy con trols. Comparative analysis of the two parameters, i.e., p53 protein levels and the corresponding antibodies in the patients revealed no correlation. (C) 1998 Elsevier Science B.V. Ail rights reserved.