Prenatal ultrasonographic diagnosis of the cerebro-costo-mandibular syndrome: Case report and review of the literature

We present an antenatal ultrasonographic diagnosis of the cerebro-costo-man dibular syndrome. This rare dysmorphic disorder (only 51 cases have been reported to date) ma inly associates defective costal development with features of the Pierre-Ro bin syndrome. The diagnosis is very often made at birth and the prognosis i s very poor. Antenatal ultrasound examination may show a combination of oro facial and chest maldevelopment. In our case the diagnosis was made at 20 weeks' gestation during a routine ultrasound examination and the patient chose to terminate the pregnancy at 24 weeks. Copyright (C) 1998 John Wiley & Sons, Ltd.