Electromagnetic exposure, fi om Extremely Low Frequency (ELF) to Radio Freq
uency (RF), at field intensity or Specific Absorption Rate (S.A.R.) values
below the current safety standards, can affect biological processes. In thi
s paper, we discuss a biophysical basis for assessing the effects of low-in
tensity ELF-RF fields, with specific emphasis on ion binding as a first int
eraction step. The actual endogenous potential energy (U-end) of the ion in
the binding crevice must be consistent with the data provided by the prote
in data bank. We developed a method for evaluating U-end from the protein d
ata, which has been incorporated in the Langevin-Lorentz (L-L) classic or i
n the Zeeman-Stark (Z-S) quantum modelling of a ligand ion-receptor protein
system. The models include a metabolic force which emulates the basal stat
e of any living cell.