Effect of concomitant injection of prostaglandin and PMSG on pregnancy rate and prolificacy of artificially inseminated Spanish goats synchronized with controlled internal drug release devices

Controlled internal drug release (CIDR) devices containing progesterone wer e used for 16 days to synchronize estrus in 108 mature Spanish does in the natural breeding season. Pregnant mare serum gonadotrophin (PMSG, 250 IU) w as given to all does 48 h prior to CIDR removal. At the time of treatment w ith PMSG, a random half of the does received prostaglandin (PGF, 5 mg dinop rost tromethamine, Lutalyse) to determine the effect of its addition on pre gnancy rates and prolificacy in artificially inseminated does, Mean pregnan cy rates, 64.5% and 59.5%, and prolificacy, 170% and 166%, were not signifi cantly different (P>0.05) for does treated with PMSG or PMSG/PGF, respectiv ely. Administering PGF to does on this synchronization regimen in the natur al breeding season is unwarranted. (C) 1999 Elsevier Science B.V. All right s reserved.