THE SPECIFIC PROTEINS OF NERVOUS-TISSUE I N ESTIMATION OF PERMEABILITY OF HEMATOENCEPHALIC BARRIER IN CHILDREN IN COMATOSE STATE

The role of functional state of hematoencephalic barrier (HEB) was est imated in terms of development of pathological process in coma. The qu antitative determination of neurospecific protein (NSP), exactly of al pha(1) and of alpha(2) cerebral globulins (produced by astrocytes and oligodendroglial cells) was used for estimation of HEB state. The clin ical examination of 138 children in comatose state caused by different factor (meningitis, encephalitis, cerebrocranial trauma, infectious t oxicosis) was performed. Enzyme immune-assay of alpha(1) and of alpha( 2) cerebral globulins allowed to control HEB's functional state object ively in <<brain-blood>> direction: in cases of alteration of HEB's fu nction the autoantibodies to NSP may penetrate into cerebral tissue an d cause nonspecific reaction in form of edema or inflammation. The mem brane stabilizing effect of Dexamethazone was established.