Parallel solid phase synthesis of tetrasubstituted diethylenetriamines viaselective amide alklylation and exhaustive reduction of N-acylated dipeptides

Polyamines are a rapidly developing area of vital importance to biomedical science. Selective N-alkylation followed by N-terminal acylation and the co mplete reduction of carbonyl amide bonds enables the preparation by paralle l solid phase synthesis of a wide range of N-1,N-5,1,4-tetrasubstituted-1,5 -diamino-3-azapentane derivatives. (C) 1998 Elsevier Science Ltd. All right s reserved.