Artificial ribonucleases: synthesis and RNA cleaving properties of cationic conjugates bearing imidazole residues

Authors
Konevetz, DA Beck, IE Beloglazova, NG Sulimenkov, IV Sil'nikov, VN Zenkova, MA Shishkin, GV Vlassov, VV
Citation
Da. Konevetz et al., Artificial ribonucleases: synthesis and RNA cleaving properties of cationic conjugates bearing imidazole residues, TETRAHEDRON, 55(2), 1999, pp. 503-512
Citations number
14
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
55
Issue
2
Year of publication
1999
Pages
503 - 512
Database
ISI
SICI code
0040-4020(19990108)55:2<503:ARSARC>2.0.ZU;2-6
Abstract
Small mimics of the ribonuclease active centre were synthesized by conjugat ing imidazole residues to a dicationic compound. These compounds were shown to cleave tRNA under physiological conditions. The compounds provide new p robes for the investigation of RNA structure in solution and potential cata lytic RNA cleaving groups for antisense oligonucleotide derivatives. (C) 19 98 Elsevier Science Ltd. All rights reserved.