Tailoring aqueous solvents for organic reactions: Heck coupling reactions in high temperature water

Authors
Gron, LU Tinsley, AS
Citation
Lu. Gron et As. Tinsley, Tailoring aqueous solvents for organic reactions: Heck coupling reactions in high temperature water, TETRAHEDR L, 40(2), 1999, pp. 227-230
Citations number
21
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
2
Year of publication
1999
Pages
227 - 230
Database
ISI
SICI code
0040-4039(19990108)40:2<227:TASFOR>2.0.ZU;2-7
Abstract
High temperature water is demonstrated to be an effective solvent for Heck coupling reactions of aromatic halides with cyclic alkenes without the addi tion of co-solvents or specialized ligands. Reactions in the presence of Li Cl and quaternary ammonium salts indicate that the reaction takes place in the aqueous phase. (C) 1998 Elsevier Science Ltd. All rights reserved.