Improved procedures for the synthesis of (S)-2-[N-(N '-benzylprolyl)amino]benzophenone (BPB) and Ni(II) complexes of Schiff's bases derived from BPB and amino acids

Authors
Belokon', YN Tararov, VI Maleev, VI Savel'eva, TF Ryzhov, MG
Citation
Yn. Belokon' et al., Improved procedures for the synthesis of (S)-2-[N-(N '-benzylprolyl)amino]benzophenone (BPB) and Ni(II) complexes of Schiff's bases derived from BPB and amino acids, TETRAHEDR-A, 9(23), 1998, pp. 4249-4252
Citations number
7
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
9
Issue
23
Year of publication
1998
Pages
4249 - 4252
Database
ISI
SICI code
0957-4166(199812)9:23<4249:IPFTSO>2.0.ZU;2-8
Abstract
(S)-N-Benzylproline (BP) was obtained by the reaction of (S)-proline and be nzylchloride in high chemical yield (89%). (S)-2-[N-(N'-Benzylprolyl)amino] benzophenone (BPB) was synthesized in amounts greater than 100 g by the SOC l2 promoted condensation of BP with 2-aminobenzophenone (yield 82%). Ni(IT) complexes of Schiff's bases derived from BPB and amino acids were prepared by an improved procedure involving the use of KOH as a base and MeOH as so lvent (yield 90-91%). (C) 1998 Elsevier Science Ltd. All rights reserved.