PECULIARITIES OF BLOOD LIPID TRANSPORT-SY STEM IN MALES AFTER AMPUTATION OF THE LOWER-LIMBS

A comparative analysis of major blood lipoprotein values in 108 males aged 16-65 years with lower limbs amputations has shown a higher level of triglycerides (TG) and a reduced level of high density lipoprotein cholesterol (HDL C) in them than in control males with normal limbs. In the subgroup of patients who had undergone the amputation as a resu lt of obliterative arterial disease, the TG level was the highest whil e HDL C the lowest; moreover, these values appeared to be the same as iii the age-matched subgroup of patients with manifestations of athero sclerosis. In the subgroup of older men with posttraumatic lower limb amputations (aged 40-59 years) the TG and HDL C levels did not differ from the corresponding parameters in age-matched subgroup of healthy s ubjects, whereas young amputees (17-39 years) had the increased blood TG concentration and reduced level of HDL C and apolipoprotein AI. The conclusion is made: disability following limb amputation accompanied by restricted mobility, inadequate physical static efforts as well as by chronic psychological stress seem especially dangerous for young in valids because of associated lipoprotein profile changes which call be regarded as highly atherogenic.