H. Maiwald et al., LONG-TERM PERSISTENCE OF ANTI-HAV ANTIBODIES FOLLOWING ACTIVE IMMUNIZATION WITH HEPATITIS-A VACCINE, Vaccine, 15(4), 1997, pp. 346-348
Seventy-one anti-hepatitis A virus (HAV) negative volunteers were immu
nized against hepatitis A. An inactivated hepatitis A vaccine (HAVRIX,
SmithKline Beecham), derived from tissue cell cultures, at single dos
es of 720 ELISA units was used following a schedule of vaccinations at
month 0, 1 and 6. The vaccinees were tested for the presence of HAV a
ntibodies 1 month after each vaccination and then after 2, 3, 4 and 5
years. The annual decrease of anti-HAV titres was 25%. Five years afte
r vaccination a protective antibody titre, varying between 20 and 5200
mIU ml(-1), could be demonstrated in all 47 retested volunteers with
a geometric mean titre (GMT) of 442 mIU ml(-1). Levels of anti-HAV-ant
ibodies following active immunization were significantly higher in fem
ale volunteers. This could be consistently demonstrated throughout the
observation period. Based on these darn the antibody persistence was
calculated over time. GMTs at protective levels higher than 20 mIU ml(
-1) can be expected to persist for at least 15 years. (C) 1997 Publish
ed by Elsevier Science Ltd.