Retroperitoneal sarcomas are rare tumours. Although exceptional in the meso
colon, they can yet be considered as a special kind of retroperitoneal tumo
urs. Leiomyosarcoma represents from 25 to 30% in this location. Clinical fe
atures are rarely obvious because the symptomatology depends upon displaced
or compressed adjacent organs. Most authors agree on using the CT-scanner
or MRI as diagnostic tools. However, the diagnosis is made after a histolog
ic examination permitting the establishment of its grade and margins. Only
a surgical treatment can offer prolonged survival and this can be improved
if there is a low histological grade and total excision. The mesocolic loca
tion facilitates a radical removal and may therefore offer a better long-te
rm prognosis.