Objective: The authors examined whether Continuous Performance Test scores
correlate with frontosubcortical volumes in bipolar disorder. Method: The s
ubjects were 17 patients hospitalized for an acute manic episode and 12 gro
up-matched comparison subjects. They underwent magnetic resonance imaging a
nd completed the Continuous Performance Test, Results: The patients perform
ed worse on the Continuous Performance Test and had smaller prefrontal cort
ical volumes than the comparison subjects. Within the patient group, Contin
uous Performance Test performance significantly correlated with prefrontal
and hippocampal volumes. Conclusions: These results suggest that certain ne
uroanatomic structures may be associated with attentional dysfunction in ma
nia.