Juvenile polyposis occurring in hereditary hemorrhagic telangiectasia

Various extraintestinal manifestations may occur in juvenile polyposis, but hereditary hemorrhagic telangiectasia has rarely been reported in this typ e of polyposis. The authors treated a 14-year-old girl with rectal bleeding and anemia who had multiple polyps of the colorectum. Large polyps were re moved and histologically diagnosed as juvenile polyps. She was later diagno sed as having telangiectasia of the skin, and arteriovenous malformations i n the lung and in the liver, all of which were compatible with the diagnosi s of hereditary hemorrhagic telangiectasia. At age 32, she had multiple ulc ers in the ileum and in the colon. The coexistence of juvenile polyposis an d hereditary hemorrhagic telangiectasia may be a clue for the understanding of the histopathogenesis of juvenile polyposis.