Proteoglycan composition in cell nuclei of mouse hepatoma

Cell nuclei of mouse hepatoma contain various proteoglycans (PG) which incl ude heparan sulfate proteoglycan (HS-PG), dermatan sulfate proteoglycan (DS -PG), and chondroitin sulfate proteoglycan (CS AC-G). The latter is not fou nd in cell nuclei of normal mouse liver. Heparan sulfate (HS) and dermatan sulfate (DS) are the main constituents of carbohydrate chains of nuclear pr oteoglycans of tumor and normal cells, respectively. Changes in the composi tion of nuclear PG during malignant transformation are discussed considerin g the concept of their possible involvement in the regulation of cell mitot ic activity.