The design, synthesis, and evaluation of novel conformationally rigid analogues of sialyl Lewis(x)

Authors
Murphy, PV Hubbard, RE Manallack, DT Wills, RE Montana, JG Taylor, RJK
Citation
Pv. Murphy et al., The design, synthesis, and evaluation of novel conformationally rigid analogues of sialyl Lewis(x), BIO MED CH, 6(12), 1998, pp. 2421-2439
Citations number
44
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
09680896 → ACNP
Volume
6
Issue
12
Year of publication
1998
Pages
2421 - 2439
Database
ISI
SICI code
0968-0896(199812)6:12<2421:TDSAEO>2.0.ZU;2-I
Abstract
The design and synthesis of a series of analogues of sialyl Lewis(x) (1) wh ich incorporate conformationally rigid tetralin and naphthalene ring system s (2-4) has led to novel compounds which have similar potency to 1 as inhib itors of cell adhesion. (C) 1998 Published by Elsevier Science Ltd. All rig hts reserved.