Syntheses and preventive effects of analogues related to 1 alpha,25-dihydroxy-2 beta-(3-hydroxypropoxy)vitamin D-3 (ED-71) on bone mineral loss in ovariectomized rats

Authors
Ono, Y Kawase, A Watanabe, H Shiraishi, A Takeda, S Higuchi, Y Sato, K Yamauchi, T Mikami, T Kato, M Tsugawa, N Okano, T Kubodera, N
Citation
Y. Ono et al., Syntheses and preventive effects of analogues related to 1 alpha,25-dihydroxy-2 beta-(3-hydroxypropoxy)vitamin D-3 (ED-71) on bone mineral loss in ovariectomized rats, BIO MED CH, 6(12), 1998, pp. 2517-2523
Citations number
12
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
09680896 → ACNP
Volume
6
Issue
12
Year of publication
1998
Pages
2517 - 2523
Database
ISI
SICI code
0968-0896(199812)6:12<2517:SAPEOA>2.0.ZU;2-A
Abstract
Analogues related to 1 alpha,25-dihydroxy-2 beta-(3-hydroxypropoxy)vitamin D-3 (ED-71) (2), 26,27-dimethyl ED-71 (3) and 26,27-diethyl ED-71 (4), were synthesized from lithocholic acid (5). In the study of the preventive effe cts of these analogues and ED-71 (2) on bone mineral loss in ovariectomized rats, 26,27-dimethyl ED-71 (3) showed the most potent activity. (C) 1998 E lsevier Science Ltd. All rights reserved.