Synthesis and evaluation of potent and selective c-GMP phosphodiesterase inhibitors

Authors
Ho, GD Silverman, L Bercovici, A Puchalski, C Tulshian, D Xia, Y Czarniecki, M Green, M Cleven, R Zhang, HT Fawzi, A
Citation
Gd. Ho et al., Synthesis and evaluation of potent and selective c-GMP phosphodiesterase inhibitors, BIOORG MED, 9(1), 1999, pp. 7-12
Citations number
7
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
1
Year of publication
1999
Pages
7 - 12
Database
ISI
SICI code
0960-894X(19990104)9:1<7:SAEOPA>2.0.ZU;2-3
Abstract
Syntheses and structure-activity relationships (SAR) of cGMP selective phos phodiesterase inhibitors are discussed. Potent and selective inhibitors are produced when the C-2 position of tetracyclic guanine 1 is substituted wit h alkyl chains containing six carbon atoms, (C) 1998 Elsevier Science Ltd. All rights reserved.