Inhibition of transforming growth factor-beta 2 expression with phosphorothioate antisense oligonucleotides in U937 cells

Authors
Shen, ZJ Kim, SK Lee, YS Lee, JW Moon, BJ
Citation
Zj. Shen et al., Inhibition of transforming growth factor-beta 2 expression with phosphorothioate antisense oligonucleotides in U937 cells, BIOORG MED, 9(1), 1999, pp. 13-18
Citations number
26
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
1
Year of publication
1999
Pages
13 - 18
Database
ISI
SICI code
0960-894X(19990104)9:1<13:IOTGF2>2.0.ZU;2-H
Abstract
Four types of phosphorothioate antisense oligonucleotides for transforming growth factor-beta 2 were synthesized and tested for their antisense activi ty in U937 cells. The full-length phosphorothioate modified antisense analo gues exhibited the highest inhibitory effects on the transforming growth fa ctor-beta 2 expression in U937 cells. (C) 1998 Elsevier Science Ltd. All ri ghts reserved.