A study of novel antiallergic agents with eosinophilic infiltration inhibiting action

Authors
Kawasaki, N Miyataka, H Matsumoto, H Yamashita, N Sakane, T Mizushima, Y Satoh, T
Citation
N. Kawasaki et al., A study of novel antiallergic agents with eosinophilic infiltration inhibiting action, BIOORG MED, 9(1), 1999, pp. 19-24
Citations number
13
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
1
Year of publication
1999
Pages
19 - 24
Database
ISI
SICI code
0960-894X(19990104)9:1<19:ASONAA>2.0.ZU;2-9
Abstract
The antiallergic action of a series of novel mono-O-substituted trimethylhy droquinones was investigated. Among this series of the compounds, 4-[4-[4-( diphenylmethyl)-1-piperazinyl]butoxy]-2,3,6-trimethylphenol (compound 3) sh owed a potent antihistaminic action (pA(2)=7.11) and an antiasthmatic actio n (100 mg/kg p. o.) on sensitized guinea pigs. Moreover, this compound exhi bited a strong eosinophilic infiltration inhibiting action on sensitized mi ce (100 mg/kg p. o.). (C) 1998 Elsevier Science Ltd. All rights reserved.