Chemical and enzymatic synthesis of glycoconjugates 5: One-pot regioselective synthesis of bioactive galactobiosides using a CLONEZYME (TM) thermophilic glycosidase library

Authors
Li, J Robertson, DE Short, JM Wang, PG
Citation
J. Li et al., Chemical and enzymatic synthesis of glycoconjugates 5: One-pot regioselective synthesis of bioactive galactobiosides using a CLONEZYME (TM) thermophilic glycosidase library, BIOORG MED, 9(1), 1999, pp. 35-38
Citations number
19
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
1
Year of publication
1999
Pages
35 - 38
Database
ISI
SICI code
0960-894X(19990104)9:1<35:CAESOG>2.0.ZU;2-M
Abstract
Enzymatic synthesis of galactobiosides using a versatile CLONEZYME((TM)) th ermostable glycosidase library was studied. One-pot transglycosylation reac tions were demonstrated to synthesize beta(1-->4), beta(1-->6), and alpha(1 -->6) disaccharide sequences with high regioselectivity and moderate to hig h yields. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.