Toxicity and osmoprotective activities of analogues of glycine betaine obtained by solid phase organic synthesis towards Sinorhizobium meliloti

Authors
Cosquer, A Pichereau, V Le Mee, D Le Roch, M Renault, J Carboni, B Uriac, P Bernard, T
Citation
A. Cosquer et al., Toxicity and osmoprotective activities of analogues of glycine betaine obtained by solid phase organic synthesis towards Sinorhizobium meliloti, BIOORG MED, 9(1), 1999, pp. 49-54
Citations number
22
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
1
Year of publication
1999
Pages
49 - 54
Database
ISI
SICI code
0960-894X(19990104)9:1<49:TAOAOA>2.0.ZU;2-N
Abstract
Seven analogues of the bacterial osmoprotectant glycine betaine (GB, trimet hylammonioacetate), in which the methyl groups of the Me3N+ moiety are repl aced by various substituents, were obtained by SPOS using Wang resin. Their biological activities (osmoprotection vs toxicity), appeared closely relat ed to their uptake efficiency and their catabolism in the betaine-demethyla ting model bacterium Sinorhizobium meliloti. (C) 1998 Elsevier Science Ltd. All rights reserved.