Platelet glycoprotein IIb/IIIa receptor antagonists derived from isoxazolidines

Authors
Confalone, PN Jin, FQ Mousa, SA
Citation
Pn. Confalone et al., Platelet glycoprotein IIb/IIIa receptor antagonists derived from isoxazolidines, BIOORG MED, 9(1), 1999, pp. 55-58
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
1
Year of publication
1999
Pages
55 - 58
Database
ISI
SICI code
0960-894X(19990104)9:1<55:PGIRAD>2.0.ZU;2-7
Abstract
A series of isoxazolidines has been synthesized as mimetics of the RGD sequ ence and was evaluated as antagonists of the platelet glycoprotein IIb/IIIa receptor. These compounds were shown to be highly potent GPIIb/IIIa antago nists, exhibiting submicromolar potencies. (C) 1998 The DuPont Pharmaceutic als Company. Published by Elsevier Science Ltd. All rights reserved.