Monoacetyldiglycerides as new Ca2+ mobilizing agents in rat pancreatic acinar cells

Authors
Han, SY Cho, SH Kim, SY Seo, JT Moon, SJ Jhon, GJ
Citation
Sy. Han et al., Monoacetyldiglycerides as new Ca2+ mobilizing agents in rat pancreatic acinar cells, BIOORG MED, 9(1), 1999, pp. 59-64
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
1
Year of publication
1999
Pages
59 - 64
Database
ISI
SICI code
0960-894X(19990104)9:1<59:MANCMA>2.0.ZU;2-O
Abstract
Several monoacetyldiglycerides were synthesized from glycerol in search fbr new Ca2+ mobilizing agent in vitro. All monoacetyldiglycerides except lino lenoyl and phenlycyclopropylcarbonyl derivatives showed activity toward Ca2 + release in pancreatic acinar cells. Linoleoyl and docosahexaenoyl derivat ives were chosen for further test and exhibited unique activity. (C) 1998 E lsevier Science Ltd. All rights reserved.