Synthesis and biological evaluation of novel cryptophycin analogs with modification in the beta-alanine region

Authors
Shih, C Gossett, LS Gruber, JM Grossman, CS Andis, SL Schultz, RM Worzalla, JF Corbett, TH Metz, JT
Citation
C. Shih et al., Synthesis and biological evaluation of novel cryptophycin analogs with modification in the beta-alanine region, BIOORG MED, 9(1), 1999, pp. 69-74
Citations number
9
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
1
Year of publication
1999
Pages
69 - 74
Database
ISI
SICI code
0960-894X(19990104)9:1<69:SABEON>2.0.ZU;2-H
Abstract
Structure modification of the beta-alanine region (fragment C) of the poten t antimitotic agent cryptophycin was investigated. This includes: (1) intro duction of substituents at the previously unsubstituted C7 position of the macrolide ring and (:2) replacement of the (2R)-3-amino-2-methyl-propanoic acid (beta-alanine) with various (1)-amino acids to give the corresponding 15-membered unnatural cryptophycin analogs. (C) 1998 Elsevier Science Ltd. All rights reserved.