Azaindole derivatives with high affinity for the dopamine D4 receptor: Synthesis, ligand binding studies and comparison of molecular electrostatic potential maps

Authors
Lober, S Hubner, H Gmeiner, P
Citation
S. Lober et al., Azaindole derivatives with high affinity for the dopamine D4 receptor: Synthesis, ligand binding studies and comparison of molecular electrostatic potential maps, BIOORG MED, 9(1), 1999, pp. 97-102
Citations number
23
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
1
Year of publication
1999
Pages
97 - 102
Database
ISI
SICI code
0960-894X(19990104)9:1<97:ADWHAF>2.0.ZU;2-R
Abstract
Piperazinylmethyl substituted pyrazolo[1,5-a]pyridines and related heterocy cles were synthesized and found to recognize selectively the dopamine D4 re ceptor. For the most potent derivative 10d a Ki value of 2.0 nM was observe d. SAR studies including the comparison of molecular isopotential surfaces were performed. (C) 1998 Elsevier Science Ltd. All rights reserved.