Novel cytotoxic diterpenes from the stem of Dysoxylum kuskusense

Authors
Fujioka, T Yamamoto, M Kashiwada, Y Fujii, H Mihashi, K Ikeshiro, Y Chen, IS Lee, KH
Citation
T. Fujioka et al., Novel cytotoxic diterpenes from the stem of Dysoxylum kuskusense, BIOORG MED, 8(24), 1998, pp. 3479-3482
Citations number
8
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
8
Issue
24
Year of publication
1998
Pages
3479 - 3482
Database
ISI
SICI code
0960-894X(199812)8:24<3479:NCDFTS>2.0.ZU;2-Y
Abstract
Three novel diterpenes, dysokusones A (1), B (2), and C (3), were isolated from the stem of Dysoxylum kuskusense as cytotoxic substances. The structur es were established by spectroscopic examinations. Compounds 1, 2, and 3 we re cytotoxic toward HL-60(TB) cells with EC50 values of 2.25, 6.35, and 2.3 7 mu M, respectively. Compound 1 also displayed cytotoxicity against K-562 and NCI-H522 cells with EC50 values of 5.04 and 4.80 mu M, respectively. (C ) 1998 Elsevier Science Ltd. All rights reserved.