Design and synthesis of new secretory phospholipase A(2) inhibitor of a phospholipid analog

Authors
Iwama, S Segawa, M Fujii, S Ikeda, K Katsumura, S
Citation
S. Iwama et al., Design and synthesis of new secretory phospholipase A(2) inhibitor of a phospholipid analog, BIOORG MED, 8(24), 1998, pp. 3495-3498
Citations number
10
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
8
Issue
24
Year of publication
1998
Pages
3495 - 3498
Database
ISI
SICI code
0960-894X(199812)8:24<3495:DASONS>2.0.ZU;2-C
Abstract
All stereoisomers of N-acyl-4,5-disubstituted oxazolidinone phospholipid an alogs were synthesized by regio and stereoselective epoxide ring opening ac companied by introduction of an amino group. The (4R,5S)-derivative showed stronger inhibitory activity toward type II phospholipase A, than the 4-sub stituted oxazolidinone phospholipid analog previously reported. (C) 1998 El sevier Science Ltd. All rights reserved.